1797989-42-4 | CHIR-99021 monohydrochloride
Potent and selective inhibitor of the glycogen synthase kinase GSK-3. Promotes cell renewal in embryonic stem cells by modulating Notch, MAPK and TGF- signalling pathways, which are involved in pluripotency.
It also affects the Wnt/ -catenin pathway and alters expression of genes coding for proteins, epigenetic regulatory elements and non-coding RNAs. The combination of CHIR 99021 and basic fibroblast growth factor (bFGF) allows long-term self-renewal in adult mouse retinal progenitor cells.
CHIR 99021 hydrochloride;
3-Pyridinecarbonitrile, 6-[[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-, hydrochloride (1:1);
CAS 1797989-42-4|CHIR-99021 monohydrochloride
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1797989-42-4 |
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C22H19Cl3N8 |
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501.8 |
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Greater than or equal to 25.1 mg/mL in DMSO; Greater than or equal to 4.23 mg/mL in H2O; Greater than or equal to 4.83 mg/mL in EtOH |
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P 1797989-42-4|CHIR-99021 monohydrochloride
Package:0.1g,1g,5g,25g,100g,500g,1kg
of CAS 1797989-42-4|CHIR-99021 monohydrochloride
[HTML] Glycogen synthase kinase-3 mediates proinflammatory cytokine secretion and adipogenesis in orbital fibroblasts from patients with Graves' orbitopathy
JS Lee, MK Chae, DO Kikkawa… - … & visual science, 2020 - iovs.arvojournals.org
… 3 inhibitor CHIR 99021 for … CHIR 99021 was applied in concentrations up to 20 µM for at
least 72 hours. Based on these results, when analyzing the effect of CHIR 99021, CHIR 99021 …
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